Tom Cruise ... Jerry Maguire
Cuba Gooding Jr. ... Rod Tidwell
Renee Zellweger ... Dorothy Boyd (as Renee Zellweger)
Kelly Preston ... Avery Bishop
Jerry O'Connell ... Frank Cushman
Jay Mohr ... Bob Sugar
Bonnie Hunt ... Laurel Boyd
Regina King ... Marcee Tidwell
Jonathan Lipnicki ... Ray Boyd
Todd Louiso ... Chad the Nanny
Mark Pellington ... Bill Dooler
Jeremy Suarez ... Tyson Tidwell
Jared Jussim ... Dicky Fox
Benjamin Kimball Smith ... Keith Cushman
Ingrid Beer ... Anne-Louise
Jann Wenner ... Scully
Nada Despotovich ... Wendy
Alexandra Wentworth ... Bobbi Fallon
Aries Spears ... Tee Pee
Kelly Coffield Park ... Jan (as Kelly Coffield)
Alice Marie Crowe ... Alice (as Alice Crowe)
Larina Jean Adamson ... Women's Group Member (as Larina Adamson)
Winnie Holzman ... Women's Group Member
Diana Jordan ... Women's Group Member
Susan Norfleet ... Women's Group Member
Susan Pingleton ... Women's Group Member
Cha Cha Sandoval-McMahon ... Women's Group Member (as Cha-Cha Sandoval)
Hynden Walch ... Women's Group Member
Glenn Frey ... Dennis Wilburn
Donal Logue ... Rick, Junior Agent
Tom Gallop ... Ben
Beaumont Bacon ... Cleo
Lisa Amsterdam ... Patricia Logan
Angela Goethals ... Kathy Sanders
Leslie Upson ... Flight Attendant
Rick Johnson ... John Swenson
Lightfield Lewis ... Room Service Waiter
Jerry Cantrell ... Jesus of CopyMat
Toby Huss ... Steve Remo
Drake Bell ... Jesse Remo
Christine Cavanaugh ... Mrs. Remo (as Christina Cavanaugh)
Russel Lunday ... Doctor
Eric Stoltz ... Ethan Valhere
Lamont Johnson ... Weepy Athlete
Brent Barry ... Calvin Nack
Rod Tate ... 'Baja' Brunard
Charlie Cronin ... Hootie Fan
Theo Greenly ... Hootie Fan
Danny Rimmer ... Sad Autograph Boy
Michael James Johnson ... Clark Hodd
Jordan Ross ... Art Stallings
Brandon Christianson ... Young Golfer
Jerry Ziesmer ... Trainer
Kirsten Krueger ... Draft Reporter
Shannon Thornton ... Pressbox Columnist
Luis Damian ... Mariachi Band Member
Jesus Alberto Guzman ... Mariachi Band Member
Juan Arnoldo Morales ... Mariachi Band Member
Alberto Alfavo ... Mariachi Band Member
Andrea Ferrell ... Woman in Elevator
Anthony Natale ... Man in Elevator
David Ursin ... General Manager
Thomas J. Reilly ... Reverend
Reagan Gomez-Preston ... Tidwell's Cousin
Jim Moffatt ... NFL Guest
Leo Zick ... NFL Guest
Klair Bybee ... NFL Guest
Stan Sessoms ... Shower Man (as Stanley Sessoms)
Gale Hillman ... Locker Room Athlete
Heather Cheney ... Idealized Kissing Wife
Dennis Fitzgerald ... Idealized Kissing Husband
Lucy Liu ... Former Girlfriend (as Lucy Alexis Liu)
Stephanie Furst ... Former Girlfriend
Justina Vail ... Former Girlfriend
Samantha Smith ... Former Girlfriend (as Sam Smith)
Ivana Milicevic ... Former Girlfriend (as Ivana Marina)
Lisa Rotondi ... Former Girlfriend
Lisa Stahl ... Former Girlfriend
Emily Procter ... Former Girlfriend
Amaryllis Borrego ... Former Girlfriend
Stacey A. Snyder ... Former Girlfriend (as Stacey Williams)
Lauren Parker ... Former Girlfriend
Lisa Ann Hadley ... Former Girlfriend
Kymberly Kalil ... Former Girlfriend
Alison Armitage ... Former Girlfriend
Rebecca Rigg ... Former Girlfriend
Golde Starger ... Former Girlfriend
Roy Firestone ... Roy Firestone
Al Michaels ... Al Michaels
Dan Dierdorf ... Dan Dierdorf
Frank Gifford ... Frank Gifford
Mel Kiper ... Mel Kiper
Jeffrey Lurie ... Jeff Lurie (as Jeff Lurie)
Drew Rosenhaus ... Drew Rosenhaus
Richie Kotite ... Richie Kotite
Tim McDonald ... Tim McDonald
Mike Tirico ... Self
Wayne Fontes ... Wayne Fontes
Evelyn Fontes ... Evelyn Fontes
Mike White ... Mike White
Johnnie Morton ... Johnnie Morton
Rick Mirer ... Rick Mirer
Drew Bledsoe ... Drew Bledsoe
Rob Moore ... Rob Moore
Ki-Jana Carter ... Ki-Jana Carter
Herman Moore ... Herman Moore
Art Monk ... Art Monk
Troy Aikman ... Troy Aikman
Katarina Witt ... Katarina Witt
Dean Biasucci ... Dean Biasucci
Warren Moon ... Warren Moon
Kerry Collins ... Kerry Collins
Erica Sorgi ... Erica Sorgi
Tom Friend ... Tom Friend
Dallas Malloy ... Dallas Malloy
Jim Irsay ... Jim Irsay
Meg Irsay ... Meg Irsay
Beau Bridges ... Matt Cushman (uncredited)
Michael Irvin ... Michael Irvin (uncredited)